General AML

Predicting outcome of patients with MDS after failure of AZA: validation of the North American MDS consortium scoring system

The advent of Hypomethylating Agents (HMAs) has changed the management of Myelodysplastic Syndrome (MDS) in recent years. The HMAs azacitidine…

Cynthia Umukoro , Nov 1, 2016

General AML

Acute Myeloid Leukemia in the elderly (age 70 years or older): long-term survivors

The incidence of Acute Myeloid Leukemia (AML) increases with age and the majority of cases occur in adults aged >55 years. Moreover, the…

Cynthia Umukoro , Oct 28, 2016

FLT3,   General AML

ATRA synergizes with FLT3 inhibition to eliminate FLT3/ITD1 leukemia stem cells in vitro and in vivo

The chemotherapy-free therapy All-Trans Retinoic Acid and Arsenic Trioxide (ATO/ATRA) has been reported to achieve a good response in high- and low-…

Cynthia Umukoro , Oct 27, 2016

General AML

Long-Lasting Protective Effect of Posaconazole Prophylaxis in Patients with AML Receiving Allo-HSCT

Allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT) is considered to be curative treatment in Acute Myeloid Leukemia (AML)…

Cynthia Umukoro , Oct 25, 2016

General AML

Enhancing cytotoxicity of immunotoxins in AML: Focus on BI 836858 a Fc-engineered CD33 antibody

The treatment of Acute Myeloid Leukemia (AML) is evolving at a marked pace; resistance to intensive induction chemotherapy causing deaths in elderly…

Cynthia Umukoro , Oct 20, 2016

General AML

HAG Regimen for the Treatment of AML and MDS: A Meta-Analysis with 2,314 Participants

The combination of homoharringtonine, cytarabine and G-CSF (HAG) is commonly implemented in China and Japan in Acute Myeloid Leukemia (AML) and…

Cynthia Umukoro , Oct 17, 2016

General AML

Improved outcome in AML patients enrolled in clinical trials: A national population-based cohort study of Danish intensive…

Improved data on prognosis are vital for Acute Myeloid Leukemia (AML) patients since there are high relapse rates. These data are of great use to the…

Cynthia Umukoro , Oct 14, 2016

General AML

An Editorial on Acute Myeloid Leukemia: Evidence Weak for Maintenance in Adults in CR

Rashidi A. of the Washington University School of Medicine St. Louis and his colleagues published a systematic review in the journal Blood in August…

Cynthia Umukoro , Oct 13, 2016

General AML

ESMO 2016 Congress

Copenhagen, Denmark - 07 Oct - 11 Oct 2016 The annual ESMO congress is a scientific platform for oncology research. Across disciplines and…

Cynthia Umukoro , Oct 6, 2016

General AML

Alantolactone selectively ablates AML stem and progenitor cells

Leukemic Stem Cells (LSCs), are implicated in the disease initiation and conservation of malignant cells. LSCs are particularly problematic as like…

Cynthia Umukoro , Oct 5, 2016